The annual U.S. News Best Children's Hospitals rankings, now in their 15th year, offer guidance to parents seeking the best place for their very sick child. The top 50 medical centers are ranked in 10 specialties, including pediatric cancer, pediatric cardiology & heart surgery and pediatric orthopedics.

U.S. News: Best Children's Hospitals Honor Roll 1. Boston Children's Hospital 2. Children's Hospital of Philadelphia 3. Texas Children's Hospital, Houston 4. Cincinnati Children's Hospital Medical Center 5. Children's Hospital Los Angeles

6. Children's Hospital Colorado, Aurora 7. Children's National Hospital, Washington, D.C. 8. Nationwide Children's Hospital, Columbus, Ohio 9. UPMC Children's Hospital of Pittsburgh 10. Lucile Packard Children's Hospital Stanford, Palo Alto, Calif.

For the first time this year, U.S. News also ranked children's hospitals in each state and in seven multi-state regions. These new regional rankings are designed to help families identify high-quality pediatric centers close to home. The multi-state regions, and the No. 1 hospital in each region, are:

Pacific: Children's Hospital Los Angeles Rocky Mountains: Children's Hospital Colorado, Aurora Southwest: Texas Children's Hospital, Houston Southeast: Children's Healthcare of Atlanta and Monroe Carell Jr. Children's Hospital at Vanderbilt, Nashville (tie)

Midwest: Cincinnati Children's Hospital Medical Center Mid-Atlantic: Children's Hospital of Philadelphia New England: Boston Children's Hospital

The 2022-23 rankings were created from data collected through a clinical survey sent to nearly 200 hospitals and a survey sent to thousands of pediatric doctors nationwide.

More than 4,000 physicians responded this year. Their responses were combined with those from similar surveys conducted in 2019 and 2020.